Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures
نویسندگان
چکیده
منابع مشابه
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Encapsulation of macromolecules within lipid vesicles has the potential to drive biological discovery and enable development of novel, cell-like therapeutics and sensors. However, rapid and reliable production of large numbers of unilamellar vesicles loaded with unrestricted and precisely-controlled contents requires new technologies that overcome size, uniformity, and throughput limitations of...
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15 صفحه اولDeformability of multilamellar vesicles.
Although a free unilamellar vesicle has zero or almost zero genuine surface tension, the multilamellar vesicle ("onion") exhibits a nonzero effective surface tension sigma(eff). The expression for sigma(eff) used in the literature is sigma(eff) approximately square root of kappaB/d(0), where B is the interaction modulus between the vesicle bilayers, d(0) the repeating distance between the bilay...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2001
ISSN: 0005-2736
DOI: 10.1016/s0005-2736(00)00343-6